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Susan Hurst

Pfizer

31

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Bioanalytical assays in support of tanezumab developmental and reproductive toxicity studies: challenges and learnings

2019 Bioanalysis
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Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments:

2018 Toxicologic Pathology
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From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment

2017 Toxicological Sciences
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Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model

2017 Annals of the Rheumatic Diseases
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Scientific strategies necessary to resolve FDA clinical hold on anti-nerve growth factor inhibitors: The story of tanezumab

2016 Journal of Toxicological Sciences
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Biosimilar Development: Nonclinical and Clinical Strategies and Challenges with a Focus on the Role of PK/PD Assessments

2015
- Susan Hurst
- Donghua Yin
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Key considerations in the preclinical development of biosimilars

2015 Drug Discovery Today
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Comparative Nonclinical Assessments of the Proposed Biosimilar PF-05280014 and Trastuzumab (Herceptin®)

2014 BioDrugs
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Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

2014 Reproductive Toxicology
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THU0104 Nonclinical Assessments Demonstrating the Similarity of the Proposed Biosimilar PF-05280586 and Rituximab

2013 Annals of the Rheumatic Diseases
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