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Jackie Shang

Merck & Co.

12

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284

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A two-tiered in vitro approach to de-risk drug candidates for potential bile salt export pump inhibition liabilities in drug discovery.

2020 Drug Metabolism and Disposition
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Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester

2019 Chemical Research in Toxicology
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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs

2019 Bioorganic & Medicinal Chemistry Letters
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Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.

2011 Bioorganic & Medicinal Chemistry Letters
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Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

2011 Bioorganic & Medicinal Chemistry Letters
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

2006 Journal of Medicinal Chemistry
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