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Matthew Joseph Fisher

Eli Lilly and Company

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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

2017 Bioorganic & Medicinal Chemistry Letters
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Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.

2016 Bioorganic & Medicinal Chemistry Letters
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Characterization of 3,3-dimethyl substituted N -aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors

2016 Bioorganic & Medicinal Chemistry Letters
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Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

2016 Journal of Pharmacology and Experimental Therapeutics
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Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists.

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery and characterization of a potent and selective EP4 receptor antagonist

2015 Bioorganic & Medicinal Chemistry Letters
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Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.

2015 Journal of Medicinal Chemistry
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Acid catalyzed nitrile thiolysis of 3-amino-acrylonitriles, toward the synthesis of 3,4-substituted-5-amino-isothiazoles

2015 Tetrahedron Letters
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Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.

2013 European Journal of Nuclear Medicine and Molecular Imaging
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