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Andrew W. Hardy

National Institutes of Health

25

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

2016 Bioorganic & Medicinal Chemistry Letters
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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.

2016 Journal of Medicinal Chemistry
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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

2015 Journal of Immunology
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tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells Regulation of indoleamine 2,3-dioxygenase and

2013
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type I interferon-dependent, TRAIL/DR5-mediated apoptosis CD4+ T cell death induced by infectious and noninfectious HIV-1: role of

2013
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Non-toxic inhibition of HIV-1 replication with silver–copper nanoparticles

2010 Medicinal Chemistry Research
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HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.

2009 AIDS
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Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.

2009 Journal of Immunology
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HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

2008 PLOS ONE
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PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: Restricted expression of type I interferon receptor by CCR5-expressing leukocytes

2008 Clinical Immunology
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