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R. Blake Pepinsky

Biogen Idec

79

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6717

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The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor

2021 Journal of Biological Chemistry
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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

2020 mAbs
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Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.

2019 Neurobiology of Disease
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Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II.

2015 Journal of Cell Science
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Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework

2014 Methods
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Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic

2013 CNS Drugs
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Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

2011 Nature Medicine
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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4

2011 Journal of Pharmaceutical and Biomedical Analysis
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Characterization of trisulfide modification in antibodies

2010 Analytical Biochemistry
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Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.

2010 Protein Science
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Citations (81)