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Tooru Okayama
Tooru Okayama
Daiichi Sankyo
Chemistry
Stereochemistry
Organic chemistry
Biochemistry
Pyrrolidine
6
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62
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Discovery of DS-5272 as a promising candidate: A potent and orally active p53–MDM2 interaction inhibitor
2015
Bioorganic & Medicinal Chemistry
Masaki Miyazaki
Kouichi Uoto
Yuuichi Sugimoto
Hiroyuki Naito
Keisuke Yoshida
Tooru Okayama
Haruko Kawato
Masaya Miyazaki
Mayumi Kitagawa
Takahiko Seki
S Fukutake
Masashi Aonuma
Tsunehiko Soga
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Citations (20)
Synthesis and evaluation of novel orally active p53–MDM2 interaction inhibitors
2013
Bioorganic & Medicinal Chemistry
Masaki Miyazaki
Hiroyuki Naito
Yuuichi Sugimoto
Kazuhiro Yoshida
Haruko Kawato
Tooru Okayama
Hironari Shimizu
Mayumi Kitagawa
Takahiko Seki
S Fukutake
Y Shiose
Misato Aonuma
Tsunehiko Soga
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Citations (18)
Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold.
2013
Bioorganic & Medicinal Chemistry Letters
Masaki Miyazaki
Hiroyuki Naito
Yuuichi Sugimoto
Haruko Kawato
Tooru Okayama
Hiroki Shimizu
Mayumi Kitagawa
Takahiko Seki
S Fukutake
Masashi Aonuma
Tsunehiko Soga
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Citations (24)
Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor
2013
Hironari Shimizu
S Katakura
M. Miyazaki
Hiroyuki Naito
Yuuichi Sugimoto
Haruko Kawato
Tooru Okayama
T. Soga
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Dérivés d'imidazothiazole
2007
Haruko Kawato
Masaki Miyazaki
Yuuichi Sugimoto
Hiroyuki Naito
Tooru Okayama
Tsunehiko Soga
Kouichi Uoto
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