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Helen J. Knowles

University of Oxford
Nuffield Orthopaedic Centre

63

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Loss of mutually protective effects between osteoclasts and chondrocytes in damaged joints drives osteoclast-mediated cartilage degradation via matrix metalloproteinases

2021 bioRxiv
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Osteoblast–Osteoclast Coculture Amplifies Inhibitory Effects of FG‐4592 on Human Osteoclastogenesis and Reduces Bone Resorption

2020
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The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments

2019 Cells
- Helen J. Knowles
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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

2019 Nature Communications
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Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on osteoclast formation and reduces bone resorption activity

2019 bioRxiv
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Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis.

2018 BMC Cancer
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'Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2' (vol 242, pg 322, 2017)

2017 The Journal of Pathology
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Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease

2017 Frontiers in Endocrinology
- Helen J. Knowles
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Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.

2017 The Journal of Pathology
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Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption

2015
- Helen J. Knowles
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