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Juliane Obst

Southampton General Hospital

9

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146

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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Abeta pathology

2021 bioRxiv
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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology.

2021 Cell Reports
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Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

2020 Frontiers in Immunology
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Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

2020 bioRxiv
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TREM2 knockout, but not the R47H Alzheimer’s variant, reduces neural phagocytosis and survival of human iPSC-derived macrophages

2020
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

2019 Brain
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PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration

2018 Brain Behavior and Immunity
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The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology

2018 Neuroscience
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The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity

2017 Frontiers in Aging Neuroscience
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