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Mekala Gunaratnam

University of London
University College London

55

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A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line

2018 Bioorganic & Medicinal Chemistry
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Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

2018 Journal of Medicinal Chemistry
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Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors

2015 Organic and Biomolecular Chemistry
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Macrocyclic naphthalene diimides as G-quadruplex binders

2015 Bioorganic & Medicinal Chemistry
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KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2- c ]quinolines

2015 Scientific Reports
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Indolo[3,2‐c]quinoline G‐Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G‐Quadruplex

2015 ChemMedChem
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A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.

2015 Scientific Reports
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A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus

2013 International Journal of Antimicrobial Agents
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Crystal Structure of a Promoter Sequence in the B-raf Gene Reveals an Intertwined Dimer Quadruplex.

2013 Journal of the American Chemical Society
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Bioactive compounds from Carissa spinarum

2012 Phytotherapy Research
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