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Panos Theofilas

University of California, San Francisco

34

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The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease

2021 Acta Neuropathologica
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iPSC-Induced Neurons with the V337M MAPT Mutation are Selectively Vulnerable to Caspase-Mediated Cleavage of Tau and Apoptotic Cell Death

2021
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Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation

2021 bioRxiv
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Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: diagnostic and therapeutic implications

2021 medRxiv
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Specific pattern of melanin-concentrating hormone (MCH) neuron degeneration in Alzheimer's disease and possible clinical implications

2021 medRxiv
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Hypothalamic melanin‐concentrating hormone neurons, key sleep cycle modulators, degenerate early in Alzheimer’s disease: Human neuropathology/selective vulnerability

2020 Alzheimers & Dementia
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Caspase‐6‐mediated tau cleavage and pathology in Alzheimer’s disease and other tauopathies: Developing topics

2020 Alzheimers & Dementia
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EARLY DEGENERATION OF AROUSAL SYSTEM IN ALZHEIMER'S DISEASE MAY UNDERLIE SLEEP DISTURBANCES IN PRECOGNITIVE STAGES

2019 Alzheimers & Dementia
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TAU-MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC-DERIVED HUMAN NEURONS

2019 Alzheimers & Dementia
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Profound degeneration of wake-promoting neurons in Alzheimer's disease

2019 Alzheimers & Dementia
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