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David S. Hewings

University of Oxford

26

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852

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BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

2018 Bioorganic & Medicinal Chemistry
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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

2018 Nature Communications
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Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand

2018
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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

2017 FEBS Journal
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Activity‐based probes for the multicatalytic proteasome

2017 FEBS Journal
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Isoxazole‐Derived Amino Acids are Bromodomain‐Binding Acetyl‐Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3

2016 Angewandte Chemie
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Correction to Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions

2016 ACS Chemical Biology
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Corrigendum: Organocatalytic removal of formaldehyde adducts from RNA and DNA bases.

2015 Nature Chemistry
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Discovery of small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy (DMD)

2015 Neuromuscular Disorders
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Synthesis and Crystal Structures of (RS,RS,RS)- and (1RS,2RS,3SR)-3-(N-Methylamino)cyclohexane-1,2-diol

2014 Journal of Chemical Crystallography
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