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Brian Leaker

38

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ENSIFENTRINE, A DUAL PDE 3 AND 4 INHIBITOR, PROVIDES EFFECTIVE BRONCHODILATION IN PATIENTS WITH COPD WHEN ADMINISTERED TWICE DAILY OVER 7 DAYS VIA PMDI

2021 Chest
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Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.

2020 Respiratory Research
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ENSIFENTRINE, A NOVEL DUAL PHOSPHODIESTERASE (PDE) 3 AND 4 INHIBITOR, PROVIDES EFFECTIVE BRONCHODILATION WHEN ADMINISTERED BY METERED DOSE INHALER IN PATIENTS WITH COPD

2020 Chest
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COPD sputum eosinophils; relationship to blood eosinophils and the effect of inhaled PDE4 inhibition.

2020 European Respiratory Journal
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Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD

2019 Respiratory Research
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Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

2018 The Lancet Respiratory Medicine
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LATE-BREAKING ABSTRACT: Effect of inhaled kinase inhibitor on airway inflammation assessed in induced sputum after challenge with inhaled lipopolysaccharide

2016 European Respiratory Journal
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A novel flow cytometric based method to measure kinase inhibition in sputum from COPD subjects

2016 European Respiratory Journal
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The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma.

2015 The Journal of Allergy and Clinical Immunology
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Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease

2015 British Journal of Clinical Pharmacology
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Citations (26)