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Michael J. Fossler

Trevena Inc
GlaxoSmithKline

59

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841

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Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials.

2021
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Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk.

2021 Heart Rhythm
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Functionally selective inhibition of the oxytocin receptor by retosiban in human myometrial smooth muscle.

2020 Endocrinology
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Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain.

2020 Clinical Drug Investigation
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Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

2020 Anesthesiology
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A Randomized, Placebo‐Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High‐Density Lipoprotein Cholesterol in Subjects With Dyslipidemia

2019 Clinical pharmacology in drug development
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Assessment of Demographic and Socio-Behavioral Factors on Adherence to HIV Pre-Exposure Prophylaxis Using a Markov Modeling Approach

2019 Frontiers in Pharmacology
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A First‐in‐Human Clinical Study With TRV734, an Orally Bioavailable G‐Protein–Biased Ligand at the μ‐Opioid Receptor

2019 Clinical pharmacology in drug development
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Oliceridine (TRV130), a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model

2018 The Journal of Clinical Pharmacology
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Hospitalized Patients with and without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis

2018 Therapeutic Drug Monitoring
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