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L. Michelle Lewis

Vanderbilt University

81

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Silencing of Hippocampal Neurons ROMK1 (Kir1.1) Causes Apoptosis and Chronic

2015
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Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.

2014 ACS Chemical Neuroscience
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Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity

2013
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Scheme 1, Reagents and conditions

2013
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Table 1, Structure and SAR for Analogues 12a

2013
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Table 4, SAR Analysis for rat M4 Positive Allosteric Modulators

2013
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Scaffold Hopping Affords a Highly Selective in vitro and in vivo T-Type Calcium Inhibitor Probe Free From IP Issues

2013
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Figure 2, Two MLPCN probe molecules derived from CID 3008304

2013
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Figure 6, Concentration-response curves in Ca2+ mobilization assays with M1-,M2Gqi5-, M3, M4/Gqi5-, and M5-CHO cells for CID 44602489 (M5 EC50 = 1.9 μM)

2013
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Figure 2, ML218 selectively blocks T-type Ca2+ currents without affecting voltage-gated Na+ and K+ currents in DRG neurons

2013
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