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Patrizia Carpinelli

31

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Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors

2018 Investigational New Drugs
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A phase I study of Danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy

2015 Haematologica
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31 N-Myc amplification sensitizes tumor cells to inhibition by Danusertib, an Aurora kinase inhibitor

2014 European Journal of Cancer
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517 Identification and characterization of selective MELK kinase inhibitors

2014 European Journal of Cancer
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Crystal structure of Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP

2013
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Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor

2013
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Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.

2012 Gene
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Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity.

2010 Bioorganic & Medicinal Chemistry
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Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

2010 Journal of Biological Chemistry
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Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors

2009 Journal of Clinical Oncology
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