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Abigail R. Lambert

Fred Hutchinson Cancer Research Center

20

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Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.

2020 Structure
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Original engineered variant of I-OnuI meganuclease targeting the HIV integrase gene; harbors 49 point mutations relative to wild-type I-OnuI

2017
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Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

2017 Nucleic Acids Research
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Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

2017 Nature Communications
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Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses.

2017 Protein Engineering Design & Selection
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The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease.

2016 Journal of Molecular Biology
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Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)

2016 Nucleic Acids Research
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Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity

2016 Structure
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The structural basis of asymmetry in DNA recognition and catalysis: binding and cleavage by the I-SmaMI meganuclease

2015 Acta Crystallographica Section A
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Crystal structure of LAGLIDADG homing endonuclease I-GzeII in complex with DNA target

2015
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