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Troy Harasym

University of British Columbia

44

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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.

2022 Antiviral Research
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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

2021 Nature Communications
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Prediction of nanoparticle prodrug metabolism by pharmacokinetic modeling of biliary excretion.

2013 Journal of Controlled Release
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Abstract 5464: Determination of total and encapsulated drug pharmacokinetics for CPX-351, a nanoscale liposomal fixed molar ratio of cytarabine-daunorubicin (Cyt:Daun)

2011 Cancer Research
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Liposomal encapsulation of a synergistic molar ratio of cytarabine and daunorubicin enhances selective toxicity for acute myeloid leukemia progenitors as compared to analogous normal hematopoietic cells

2011 Experimental Hematology
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Abstract 3698: Development of a hydrophobic docetaxel prodrug nanoparticle with enhanced plasma circulation lifetime and improved efficacy

2010 Cancer Research
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Schedule- and dose-dependency of CPX-351, a synergistic fixed ratio cytarabine:daunorubicin formulation, in consolidation treatment against human leukemia xenografts.

2010 Leukemia & Lymphoma
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Abstract 5534: Liposome accumulation within leukemia engrafted bone marrow is significantly enhanced when the formulation contains cytarabine plus daunorubicin

2010 Cancer Research
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Leukemia Cell–Selective Uptake of Cytarabine and Daunorubicin in the Bone Marrow Compartment Mediated by CPX-351 Liposome Injection

2010 Clinical Lymphoma, Myeloma & Leukemia
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Abstract A135: Evaluation of CPX‐351 (cytarabine:daunorubicin) liposome injection efficacy in acute lymphoblastic leukemia (ALL) xenograft models

2009 Molecular Cancer Therapeutics
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