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Kristoff T. Homan

University of Michigan

32

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750

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Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)

2017
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Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)

2017
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Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

2016 Journal of Medicinal Chemistry
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G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

2015 Journal of Biological Chemistry
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Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

2015 Journal of Biological Chemistry
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G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

2015 Biochemistry
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Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors.

2015 ACS Chemical Biology
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C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

2015 eLife
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Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor.

2014 Molecules
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Structural insights into G protein-coupled receptor kinase function.

2014 Current Opinion in Cell Biology
- Kristoff T. Homan
- John J. G. Tesmer
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