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Joseph W. Leone

Pfizer

20

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536

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Removal of N‐Terminal Blocking Groups from Proteins

2011 Current protocols in protein science
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Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family

2010 Biochemical and Biophysical Research Communications
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Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain

2010 Protein Expression and Purification
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Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

2010 Journal of Molecular Biology
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Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E. coli

2009 Protein and Peptide Letters
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Autoactivation of human ADAM8: a novel pre- processing step is required for catalytic activity

2009 Bioscience Reports
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Large-scale purification of human BACE expressed in mammalian cells and removal of the prosegment with HIV-1 protease to improve crystal diffraction.

2008 Protein and Peptide Letters
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High Yield Expression of Human BACE Constructs in Eschericia coli for Refolding, Purification, and High Resolution Diffracting Crystal Forms

2008 Protein and Peptide Letters
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Identification of an ADAMTS-4 Cleavage Motif Using Phage Display Leads to the Development of Fluorogenic Peptide Substrates and Reveals Matrilin-3 as a Novel Substrate

2007 Journal of Biological Chemistry
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Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.

2001 Molecular and Cellular Biology
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