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Catherine Dutreix

Novartis

26

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1515

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A phase 1/2, open-label, dose-escalation study of midostaurin in children with relapsed or refractory acute leukaemia

2019 British Journal of Haematology
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Simultaneous physiologically-based pharmacokinetic (PBPK) modeling of parent and active metabolites to investigate complex CYP3A4 drug-drug interaction potential: a case example of midostaurin

2018 Drug Metabolism and Disposition
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Efficacy and safety of midostaurin in patients with advanced systemic mastocytosis: 10-year median follow-up of a phase II trial

2018 Leukemia
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An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects.

2017 Clinical pharmacology in drug development
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Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth.

2016 Leukemia
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Comparison of two endogenous biomarkers of CYP3A4 activity in a drug–drug interaction study between midostaurin and rifampicin

2014 European Journal of Clinical Pharmacology
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Evaluation of the effects of the PKC412-metabolites CGP52421 and CGP62221 on proliferation and viability of neoplastic mast cells and IgE dependent secretion of histamine

2013
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Preclinical and phase i results of decitabine in combination with midostaurin (PKC412) for newly diagnosed elderly or relapsed/refractory adult patients with acute myeloid leukemia

2013 Pharmacotherapy
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Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers

2012 Cancer Chemotherapy and Pharmacology
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The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release

2011 Blood
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