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Frank Waldron-Lynch

University of Cambridge

34

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566

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The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.

2018 JCI insight
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Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile

2017 Clinical Immunology
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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

2016 PLOS Medicine
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Complement receptor 2 and IL-8 production identifies in adults and neonates naive T cells recently arising from the thymus and a Th8-like subset of memory T cells

2016 bioRxiv
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Complement receptor 2 and IL-8 production identifies in adults and neonates naive T cells recently arising from the thymus

2016 bioRxiv
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Complement receptor 2 and IL-8 production identify in humans naïve T cells recently emigrating from the thymus and a Th8-like subset of memory T cells

2016 bioRxiv
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Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

2016 bioRxiv
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Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

2015 BMJ Open
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Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D)

2015 Trials
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Simulation work in adaptive dose-finding designs to identify dose-intervals that achieve targets in multiple endpoints.

2015 Trials
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