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Ronan Le Moigne

29

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Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

2021 Science Translational Medicine
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Abstract 1209: Comprehensive in vitro characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor

2021 Cancer Research
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A phase 1 study to assess the safety, pharmacokinetics, and anti-tumor activity of the androgen receptor n-terminal domain inhibitor epi-506 in patients with metastatic castration-resistant prostate cancer.

2021 Investigational New Drugs
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Abstract 1953: Pre-clinical development of the second-generation N-terminal domain androgen receptor inhibitor, EPI-7386, for the treatment of prostate cancer

2020
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MP79-04 THE PRECLINICAL CHARACTERIZATION AND DEVELOPMENT OF EPI-7386, AN N-TERMINAL DOMAIN ANDROGEN RECEPTOR INHIBITOR, FOR THE TREATMENT OF PROSTATE CANCER

2020 The Journal of Urology
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IND candidate EPI-7386 as an N-terminal domain androgen receptor inhibitor in development for the treatment of prostate cancer.

2020 Journal of Clinical Oncology
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Abstract B117: Treatment of castrated resistant prostate cancer with EPI-7386, a second generation N-terminal domain androgen receptor inhibitor

2019 Molecular Cancer Therapeutics
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Lessons learned from the metastatic castration-resistant prostate cancer phase I trial of EPI-506, a first-generation androgen receptor N-terminal domain inhibitor.

2019 Journal of Clinical Oncology
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Next generation N-terminal domain androgen receptor inhibitors with improved potency and metabolic stability in castration-resistant prostate cancer models.

2019 Journal of Clinical Oncology
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Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia

2017 Neoplasia
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Citations (13)