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John P. Williams

Neurocrine Biosciences

34

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910

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VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine)

2018 Progress in Medicinal Chemistry
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Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

2015 Neuropsychopharmacology
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Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.

2010 Bioorganic & Medicinal Chemistry Letters
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Total Synthesis of the Lycopodium Alkaloids Magellanine and Magellaninone by Three-fold Annulation of 2-Cyclopentenone.

2010 ChemInform
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N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.

2009 Journal of Medicinal Chemistry
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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease

2008 Journal of Medicinal Chemistry
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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy

2008 Journal of Medicinal Chemistry
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Allosteric Ligands for the Corticotropin Releasing Factor Type 1 Receptor Modulate Conformational States Involved in Receptor Activation

2008 Molecular Pharmacology
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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents

2008 Journal of Medicinal Chemistry
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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A2A antagonists with improved solubility and metabolic stability

2008 Bioorganic & Medicinal Chemistry Letters
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Citations (11)