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Rolf Beume

Nycomed

88

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1217

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The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice

2012 Diabetologia
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Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

2012 British Journal of Pharmacology
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Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics

2011 Handbook of experimental pharmacology
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Phosphodiesterase Inhibitors: History of Pharmacology

2011 Handbook of experimental pharmacology
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A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

2010 Pulmonary Pharmacology & Therapeutics
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Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

2010 European Journal of Pharmacology
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The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.

2010 Pulmonary Pharmacology & Therapeutics
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EFFECTS OF ROFLUMILAST N-OXIDE, THE ACTIVE METABOLITE OF THE ORAL, ONCE-DAILY PDE4 INHIBITOR ROFLUMILAST, ON HUMAN CELLS INVOLVED IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN VITRO

2009 Chest
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Effect of roflumilast on inflammatory cell volume density in lungs of mice chronically exposed to cigarette smoke

2007
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Roflumilast prevents the increase in inflammatory cells in the lungs of mice chronically exposed to cigarette smoke: an immunohistochemical study

2007
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