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Inge Vliegen

Rega Institute for Medical Research

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Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model

2018 Antiviral Research
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In vitro combinations containing Tegobuvir are highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance.

2015 Antiviral Research
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Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon

2013 Methods of Molecular Biology
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Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus.

2013 European Journal of Medicinal Chemistry
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Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge

2012 Antiviral Research
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Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication

2011 Antimicrobial Agents and Chemotherapy
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Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

2011 Antimicrobial Agents and Chemotherapy
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DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

2010 PLOS ONE
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In vitro selection and characterization of hepatitis C virus replicons double or triple resistant to various non-nucleoside HCV polymerase inhibitors

2010 Antiviral Research
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Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

2009 Antimicrobial Agents and Chemotherapy
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