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Linda Webster

University of Alberta

18

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SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.

2021 Journal of the American Heart Association
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Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

2017 Science Translational Medicine
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Abstract 17922: Scleroderma Associated Pulmonary Arterial Hypertension is Associated With a High Prevalence of Aortic Stenosis

2016 Circulation
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Letter to the editor: Decreased SIRT3 expression is a good potential biomarker associated with diseases

2015
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Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

2014 Cell Metabolism
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Endothelin Axis Is Upregulated in Human and Rat Right Ventricular Hypertrophy

2013 Circulation Research
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Abstract 17011: Loss-of-function SIRT3 Single Nucleotide Polymorphisms in Patients With Pulmonary Arterial Hypertension (PAH): Insights into the Metabolic Basis of PAH

2013 Circulation
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Abstract 16947: Initial Brain Natriuretic Peptide Levels, but not Hemodynamics, Predict 5-Year Survival in Patients with Pulmonary Arterial Hypertension

2012 Circulation
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Metabolic Modulation of Glioblastoma with Dichloroacetate

2010 Science Translational Medicine
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Abstract 3155: Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle: Direct Implications for Patients with Pulmonary Hypertension

2006 Circulation
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