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Sean C. Shadle

Fred Hutchinson Cancer Research Center

11

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DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

2019 Developmental Cell
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DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD

2019 bioRxiv
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DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD

2019 Human Molecular Genetics
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NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

2018 eLife
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Mechanisms of toxicity in cell models of FSHD

2018
- Sean C. Shadle
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Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscle

2018 Human Molecular Genetics
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Author response: NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

2017 eLife
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BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

2017 Skeletal Muscle
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DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

2017 PLOS Genetics
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Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4

2015 Epigenetics
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