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Jamie L. McBean

Pfizer

3

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.

2011 Bioorganic & Medicinal Chemistry Letters
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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.

2011 Bioorganic & Medicinal Chemistry Letters
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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.

2011 Bioorganic & Medicinal Chemistry Letters
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