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Paul K. Spearing

Vanderbilt University

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Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2.

2021 Bioorganic & Medicinal Chemistry Letters
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Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1.

2021 Bioorganic & Medicinal Chemistry Letters
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VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

2017 ACS Medicinal Chemistry Letters
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Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core

2017 Bioorganic & Medicinal Chemistry Letters
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