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Linjie Tian

Peking University
National Institutes of Health

41

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Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

2021 eLife
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A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC410 in subjects with advanced or metastatic solid tumors.

2021 Journal of Clinical Oncology
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487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors

2021 Journal for ImmunoTherapy of Cancer
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Author response: Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

2021 eLife
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445 Blockade of the inhibitory collagen receptor LAIR-1 with NC410, a LAIR2-Fc fusion protein, enhances anti-tumor activity of the bifunctional fusion protein bintrafusp alfa

2020 Journal for ImmunoTherapy of Cancer
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694 NC410 is a novel immunomedicine for the treatment of solid tumors

2020 Journal for ImmunoTherapy of Cancer
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Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

2017 Journal of Clinical Investigation
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Abstract 4881: CD300f-regulated efferocytosis by dendritic cells and macrophages controls the initiation and resolution of experimental colitis

2016 Cancer Research
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Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock

2016 Immunity
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Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

2016 Cell Death & Differentiation
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