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Sonia Kerrad

Merck & Co.

8

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4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

2006 Bioorganic & Medicinal Chemistry Letters
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Cyclohexylsulfon derivatives as gamma-secretase inhibitors

2003
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Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.

2003 Journal of Medicinal Chemistry
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Cyclohexyl sulfone derivatives as inhibitors of gamma secretase.

2003
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Derives de benzodiazepine utilises comme modulateurs de la proteine precurseur amyloide (app)

2001
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