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Kenneth M. Humphries

Case Western Reserve University

Biochemistry
Intracellular
Chemistry
Oxidative phosphorylation
Cardiac function curve

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Earlyreperfusionofischemiccardiactissueremainsthemosteffectiveinterventionforimprovingclinicalout- comefollowingmyocardialinfarction.However,abnormalincreasesinintracellularCa 2+ duringmyocardial reperfusioncancausecardiomyocytedeathandconsequentlossofcardiacfunction,referredtoasischemia/ reperfusion(IR)injury.TherapeuticmodulationofCa 2+ handlingprovidessomecardioprotectionagainst theparadoxicaleffectsofrestoringbloodflowtotheheart,highlightingthesignificanceofCa 2+ overloadto IRinjury.CardiacIRisalsoaccompaniedbydynamicchangesintheexpressionofmicroRNAs(miRNAs);

2012
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Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

2001 Journal of Biological Chemistry
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4-hydroxy-2-nonenal mediated declines in mitochondrial respiration

1997 The FASEB Journal
- Kenneth M. Humphries
- L. I. Szweda
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