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Alexander M. Sele
Alexander M. Sele
University of Basel
PI3K/AKT/mTOR pathway
Mechanistic target of rapamycin
Cell growth
Biochemistry
Pharmacology
3
Papers
44
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A ConformationalRestriction Strategy for the Identificationof a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor
2019
Journal of Medicinal Chemistry
Chiara Borsari
Denise Rageot
Alix Dall’Asen
Thomas Bohnacker
Anna Melone
Alexander M. Sele
Eileen Jackson
Jean-Baptiste Langlois
Florent Beaufils
Paul Hebeisen
Doriano Fabbro
Petra Hillmann
Matthias P. Wymann
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Citations (13)
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase
2019
Journal of Medicinal Chemistry
Denise Rageot
Thomas Bohnacker
Erhan Keles
Jacob A. McPhail
Reece M. Hoffmann
Anna Melone
Chiara Borsari
Rohitha Sriramaratnam
Alexander M. Sele
Florent Beaufils
Paul Hebeisen
Doriano Fabbro
Petra Hillmann
John E. Burke
Matthias P. Wymann
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Citations (17)
Preclinical Development of PQR514, a Highly PotentPI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety
2019
ACS Medicinal Chemistry Letters
Chiara Borsari
Denise Rageot
Florent Beaufils
Thomas Bohnacker
Erhan Keles
Ivan Buslov
Anna Melone
Alexander M. Sele
Paul Hebeisen
Doriano Fabbro
Petra Hillmann
Matthias P. Wymann
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Citations (14)
1