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Renee Sarno

Ironwood Pharmaceuticals

16

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172

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

2020 Frontiers in Pharmacology
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Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit.

2020 Proceedings of the National Academy of Sciences of the United States of America
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The soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure

2019 American Journal of Physiology-renal Physiology
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

2018 Journal of Pharmacology and Experimental Therapeutics
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Stimulation of soluble guanylate cyclase inhibited fibrosis and inflammation in human liver microtissues and in an animal model of liver disease

2018 Journal of Hepatology
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The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis

2017 Journal of Hepatology
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Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution

2016 Circulation
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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes.

2016 Investigative Ophthalmology & Visual Science
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Differential synergy with nitric oxide across a panel of soluble guanylate cyclase stimulators

2015 The FASEB Journal
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P154 – Evaluation of methodologies to assess intracellular cGMP levels induced by soluble guanylate cyclase (sGC) stimulators in whole cells

2014 Nitric Oxide
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