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Pasquale P. Vicario

Merck & Co.

36

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Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

2010 ACS Medicinal Chemistry Letters
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Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

2009 Bioorganic & Medicinal Chemistry Letters
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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.

2008 Bioorganic & Medicinal Chemistry Letters
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Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists.

2008 Bioorganic & Medicinal Chemistry Letters
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Discovery of 3-Piperidinyl-1-cyclopentanecarboxamide as a Novel Scaffold for Highly Potent CC Chemokine Receptor 2 Antagonists

2007 Journal of Medicinal Chemistry
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Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.

2007 Bioorganic & Medicinal Chemistry Letters
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3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2

2007 Bioorganic & Medicinal Chemistry Letters
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Discovery of 3,5-bis(trifluoromethyl)benzyl l-arylglycinamide based potent CCR2 antagonists

2006 Bioorganic & Medicinal Chemistry Letters
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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

2006 Bioorganic & Medicinal Chemistry Letters
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Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists

2005 The Journal of Antibiotics
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