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Stefanie Saenger

Hoffmann-La Roche

16

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245

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Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes

2018 PLOS ONE
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Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin–Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour

2017 Growth Hormone & Igf Research
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Skeletal muscle dysfunction and mitochondrial deficits in spinal muscular atrophy (SMA)

2017 Neuromuscular Disorders
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PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia

2017 Scientific Reports
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Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1

2014 Brain
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OR2-3: The Cardin-Weintraub Motif present in IGFBP-2 is required for growth and function of the mouse brain

2014 Growth Hormone & Igf Research
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Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour

2013 Brain
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Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury

2013 Growth Hormone & Igf Research
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PEGylation of lysine residues reduces the pro-migratory activity of IGF-I

2013 Biochimica et Biophysica Acta
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Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity

2012 Amyotrophic Lateral Sclerosis
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