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Juan-Carlos Valderramos

Albert Einstein College of Medicine

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Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

2010 PLOS Pathogens
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Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

2009 Bioorganic & Medicinal Chemistry
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The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

2008 Cell Host & Microbe
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Malarial enoyl acyl ACP reductase bound with INH-NAD adduct

2007
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Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin

2006 The Journal of Infectious Diseases
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Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 5247–5252]

2006 Bioorganic & Medicinal Chemistry Letters
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Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

2006 Bioorganic & Medicinal Chemistry Letters
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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.

2005 Bioorganic & Medicinal Chemistry Letters
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