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Alex Toker

Beth Israel Deaconess Medical Center
Harvard University
Boston Biomedical Research Institute

254

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FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance.

2021 Nature Cell Biology
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The KRAS-G12D Mutation Induces Metabolic Vulnerability in B-Cell Acute Lymphoblastic Leukemia

2021 Social Science Research Network
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Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer

2021
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Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

2021 PLOS Genetics
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Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer.

2020 Cancer Cell
- Alissandra L. Hillis
- Alex Toker
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Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

2020 bioRxiv
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Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

2020 Journal of Biological Chemistry
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Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia.

2020 PLOS ONE
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Double trouble for cancer gene

2019 Science
- Alex Toker
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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors

2018 Science Signaling
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Citations (22)