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James J. Schmidt

United States Army Medical Research Institute of Infectious Diseases

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Primary Neurons Mode to a Small Molecule That Is Active in Serotype A from a Pseudo-peptide Binding Inhibition of Metalloprotease Botulinum Enzyme Catalysis and Regulation:

2014
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Rapid product analysis and increased sensitivity for quantitative determinations of botulinum neurotoxin proteolytic activity

2010 Analytical Biochemistry
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Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E†

2008 Applied and Environmental Microbiology
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Peptide-Toxin Tools for Probing the Expression and Function of Fetal and Adult Subtypes of the Nicotinic Acetylcholine Receptor

2008 Annals of the New York Academy of Sciences
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Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore

2008 ChemMedChem
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Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons

2007 Journal of Biological Chemistry
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Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A

2007 PLOS ONE
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Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

2006 Bioorganic & Medicinal Chemistry
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Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A

2006 Bioorganic & Medicinal Chemistry
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Integrated Bioassays in Microfluidic Devices: Botulinum Toxin Assays

2005 Journal of Biomolecular Screening
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