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Hossain Monshizadegan

Bristol-Myers Squibb

26

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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

2016 ACS Medicinal Chemistry Letters
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Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

2010 Journal of Medicinal Chemistry
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Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation

2010 Bioorganic & Medicinal Chemistry Letters
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(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential

2008 Journal of Medicinal Chemistry
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Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2‘-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics

2005 Journal of Medicinal Chemistry
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A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes.

2005 Bioorganic & Medicinal Chemistry Letters
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Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

2004 Journal of Medicinal Chemistry
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Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase

2004 Bioorganic & Medicinal Chemistry Letters
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Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension

2004 Journal of Pharmacology and Experimental Therapeutics
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Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity

2004 American Journal of Physiology-heart and Circulatory Physiology
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Citations (94)