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Nadia Moretto

Chiesi Farmaceutici S.p.A.

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The PDE4 inhibitor CHF6001 modulates pro-inflammatory cytokines, chemokines and Th1- and Th17-polarizing cytokines in human dendritic cells

2019 Biochemical Pharmacology
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Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases

2017 Journal of Medicinal Chemistry
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In vitropharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery

2016 European Respiratory Journal
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CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.

2015 Journal of Pharmacology and Experimental Therapeutics
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Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases

2014 Journal of Medicinal Chemistry
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In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile

2014 European Respiratory Journal
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Cigarette smoke upregulates IL-8/CXCL8 expression by augmenting mRNA stability via p38 MAPK/MK2 signalling in normal human pulmonary cells

2012 European Respiratory Journal
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Pharmacological inhibition of epidermal growth factor receptor modulates cigarette smoke-induced CXCL8 release but not VEGF release

2012 European Respiratory Journal
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Cigarette Smoke And Acrolein Upregulate IL-8 Expression By Enhancing IL-8 MRNA Stabilization Via P38 MAPK/MK2 Signaling In Human Bronchial Smooth Muscle Cells

2012 ATS | American Thoracic Society International Conference
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Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease

2012 Annals of the New York Academy of Sciences
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