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Hidehito Kotani

Merck & Co.

39

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MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

2010 Cancer Biology & Therapy
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Structures of the PKC‐ι kinase domain in its ATP‐bound and apo forms reveal defined structures of residues 533–551 in the C‐terminal tail and their roles in ATP binding

2010 Acta Crystallographica Section D-biological Crystallography
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Gene expression-based pharmacodynamic biomarkers: the beginning of a new era in biomarker-driven anti-tumor drug development.

2010 Current Molecular Medicine
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MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

2010 Molecular Cancer Therapeutics
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Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

2010 Cell Cycle
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Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements

2010 Human Genetics
- Shinji Mizuarai
- Hidehito Kotani
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Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors

2009 Bioorganic & Medicinal Chemistry Letters
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High-Throughput Assay for Long Chain Fatty Acyl-CoA Elongase Using Homogeneous Scintillation Proximity Format

2009 Assay and Drug Development Technologies
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Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis

2009 Gastroenterology
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Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines.

2009 Molecular Cancer Therapeutics
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