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Alexander M. Long

Amgen

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Development of an automated mid-scale parallel protein purification system for antibody purification and affinity chromatography.

2016 Protein Expression and Purification
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Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor

2015
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Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK).

2015 Journal of Medicinal Chemistry
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Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.

2014 Journal of Medicinal Chemistry
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Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity

2014 Cancer Cell
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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

2014 Journal of Medicinal Chemistry
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Co-crystal structure of MDM2 with Inhibitor Compound 4

2014
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Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction.

2014 Journal of Medicinal Chemistry
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Abstract 2275: Characterization of the mechanistic basis of Apo2L/TRAIL-AMG 655-dr5 interactions and cooperative signaling in cancer cells

2014 Cancer Research
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Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.

2014 Bioorganic & Medicinal Chemistry Letters
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Citations (6)