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Giulia Agnello

University of Texas at Austin

15

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115

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Arginase therapy combines effectively with checkpoint blockade or agonist anti-OX40 immunotherapy to control tumor growth.

2021 Cancer immunology research
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MP43-05 ENZYMATIC LOWERING OF PLASMA CYSTINE PREVENTS FORMATION AND GROWTH OF STONES IN A MOUSE MODEL OF CYSTINURIA UNDER DEHYDRATION CHALLENGE

2020 The Journal of Urology
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Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1

2019 Translational Research
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Abstract 3964: Reducing systemic arginine with arginase (AEB1102) therapy does not suppress the immune response induced by anti-PD-1 and anti-PD-L1, and exerts an additive anti-tumor and synergistic survival benefit

2017 Cancer Research
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Abstract 1042: Development of AEB1102, an engineered human arginase 1 for patients with solid tumors

2016 Cancer Research
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A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration.

2016 Human Molecular Genetics
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Development of a Human Therapeutic L-Cyst(e)Ine-Degrading Enzyme for the Treatment of Hematological Malignancies

2016 Blood
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Identification of a mutation in ASRGL1 as the underlying cause of early-onset recessive Retinal Degeneration (RD).

2015 Investigative Ophthalmology & Visual Science
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Discovery of a substrate selectivity motif in amino acid decarboxylases unveils a taurine biosynthesis pathway in prokaryotes.

2013 ACS Chemical Biology
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Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer

2012 Methods in Enzymology
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Citations (31)