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Michael F. Belcourt

Yale University

21

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Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

2004 Molecular Pharmacology
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Nuclear Overexpression of NAD(P)H:Quinone Oxidoreductase 1 in Chinese Hamster Ovary Cells Increases the Cytotoxicity of Mitomycin C under Aerobic and Hypoxic Conditions

2004 Journal of Biological Chemistry
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Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone

2001 Journal of Biological Chemistry
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Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol 4 4Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.

2001 Biochemical Pharmacology
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Reversal of Mitomycin C Resistance by Overexpression of Bioreductive Enzymes in Chinese Hamster Ovary Cells

2001 Cancer Research
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Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

2000 Chemical Research in Toxicology
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Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

1999 Proceedings of the National Academy of Sciences of the United States of America
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2016 Effects of microenvironmental factors on the uptake, metabolism, and cytotoxicity of the bioreductive alkylating agents

1999 International Journal of Radiation Oncology Biology Physics
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Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines

1999 Journal of Medicinal Chemistry
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Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.

1998 Oncology Research
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