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Eugen Lounkine

Novartis

54

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1696

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Evolution of Novartis’ Small Molecule Screening Deck Design

2020 Journal of Medicinal Chemistry
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Gene-signatures predict biologically relevant dose-response potencies in phenotypic assays

2019 bioRxiv
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Cheminformatics Tools for Analyzing and Designing Optimized Small Molecule Collections and Libraries

2018
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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

2018 Journal of Medicinal Chemistry
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The Importance of Reverse Translation for Preclinical Off-Target Mitigation: Quantification and Mitigation of Biases in the FDA Adverse Event Reporting System

2017 bioRxiv
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Author response: Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

2017 eLife
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The Powers and Perils of Post-Marketing Data Analysis: Quantification and Mitigation of Biases in the FDA Adverse Event Reporting System

2016 bioRxiv
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Dark chemical matter as a promising starting point for drug lead discovery

2015 Nature Chemical Biology
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Experimental Design Strategy: Weak Reinforcement Leads to Increased Hit Rates and Enhanced Chemical Diversity

2015 Journal of Chemical Information and Modeling
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The opportunities of mining historical and collective data in drug discovery.

2015 Drug Discovery Today
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