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Jin Hong

Janssen Pharmaceutica

13

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374

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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

2016 PLOS ONE
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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

2015 Journal of Medicinal Chemistry
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The Anti-Respiratory Syncytial Virus (RSV) Nucleoside Analog, AL-8112, and its Orally Bioavailable Prodrug, AL-8176, Exhibit a High Barrier to the Emergence of Viral Resistance

2015 Open Forum Infectious Diseases
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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

2015 PLOS Pathogens
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5’- C -Alkylated analogs of gemcitabine: antiviral and anticancer properties

2014 Collection of Czechoslovak Chemical Communications
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257 : Development of a hyperglycosylated interferon ALFACON1: Towards monthly dosing for antiviral therapies in diseases such as chronic hepatitis C

2013 Cytokine
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Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution

2012 Antimicrobial Agents and Chemotherapy
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PS2-39 Development of a hyperglycosylated IFN alfacon1 (CIFN): Towards once a month dosing for antiviral therapy

2010 Cytokine
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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

2008 Antimicrobial Agents and Chemotherapy
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Variants de polypeptides synthetiques hyperglycosyles, et resistants a la protease, formulations orales et leurs procedes d'utilisation

2005
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