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James A. Yergey

Merck & Co.

18

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Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

2011 ACS Chemical Neuroscience
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Improving Metabolic Stability of Phosphodiesterase-4 Inhibitors Containing a Substituted Catechol: Prevention of Reactive Intermediate Formation and Covalent Binding.

2010 ChemInform
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Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

2007 Journal of Medicinal Chemistry
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Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

2002 Bioorganic & Medicinal Chemistry Letters
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Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.

2002 Bioorganic & Medicinal Chemistry Letters
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In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

2001 Bioorganic & Medicinal Chemistry Letters
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Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

1999 Analytical Biochemistry
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Mass spectrometric analysis of arachidonyl-containing phospholipids in human U937 cells.

1999 Journal of Mass Spectrometry
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Continuous flow liquid secondary ion mass spectrometric characterization of phospholipid molecular species

1997 Journal of Mass Spectrometry
- Chun Li
- James A. Yergey
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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

1996 Journal of Medicinal Chemistry
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