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Tetsuo Uno

Genomics Institute of the Novartis Research Foundation

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Tuning a Protein Labeling Reaction to Achieve Highly Site-Selective Lysine Conjugation.

2018 ChemBioChem
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Conjugués d'anticorps comprenant un agoniste du récepteur de type toll

2016
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Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.

2016 Bioorganic & Medicinal Chemistry Letters
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Dérivés d'auristatine et conjugués de ceux-ci

2015
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Syk inhibitors with high potency in presence of blood.

2014 Bioorganic & Medicinal Chemistry Letters
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Novel Syk inhibitors with high potency in presence of blood

2014 Bioorganic & Medicinal Chemistry Letters
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Site‐Specific Dual Labeling of Proteins by Using Small Orthogonal Tags at Neutral pH

2014 ChemBioChem
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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.

2013 Journal of Medicinal Chemistry
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Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins.

2012 ChemBioChem
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D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine

2011 Nature Chemical Biology
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Citations (28)