author-photo

Toru Horie

Eisai

71

Papers

1747

Citations

Citation Trend

Filter By

Papers (53) Sort By

Journal Conference Others

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry

2016 Chemical Research in Toxicology
Show All
- Source
- Cite
- Save
Citations (11)
Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

2015 Xenobiotica
Show All
- Source
- Cite
- Save
Citations (32)
Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

2015 Toxicology Research
Show All
- Source
- Cite
- Save
Citations (9)
Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates

2014 Toxicology in Vitro
Show All
- Source
- Cite
- Save
Citations (9)
Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

2014 Drug Metabolism and Disposition
Show All
- Source
- Cite
- Save
Citations (28)
Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.

2013 Xenobiotica
Show All
- Source
- Cite
- Save
Citations (14)
Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

2012 Drug Metabolism and Disposition
Show All
- Source
- Cite
- Save
Citations (56)
EVALUATION OF DONOR DEPEDENCIES IN PROTEIN EXPRESSION OF TRANSPORTERS AND METABLIC ENZYMES IN HUMANIZED LIVER OF CHIMERIC MICE

2010
Show All
- Source
- Cite
- Save
Citations (0)
Approach for in Vivo Protein Binding of 5-n-Butyl-pyrazolo[1,5-a]pyrimidine Bioactivated in Chimeric Mice with Humanized Liver by Two-Dimensional Electrophoresis with Accelerator Mass Spectrometry

2010 Chemical Research in Toxicology
Show All
- Source
- Cite
- Save
Citations (30)
HIGH MAINTENANCE CAPACITY OF A NOVEL THREE-DIMENTIONAL CULTURE SYSTEM USING MICRO-SPACE PLATES FOR mRNA EXPRESSION LEVELS OF PHARMACOKINETICS-RELATED PROTEINS IN HUMAN HEPATOCYTES

2010
Show All
- Source
- Cite
- Save
Citations (0)